Stephen Manuck, Ph.D.


501 OEH

Pittsburgh, PA 15213





Research Interests

Psychosocial antecedents of cardiovascular disease; genetics of behavior and gene-environment interaction; neurobiology of personality and temperament.


Download CV here

Accepting Graduate Students: No

Graduate Student Advisees

  • Miller, Karissa
  • Wong, Patricia


  • PhD, Vanderbilt University


  • Vanderbilt University Psychological Sciences Distinguished Alumnus Award (2013)
  • American Psychosomatic Society Patricia R. Barchas Award (2012)
  • Academy of Behavioral Medicine Research, President (2012)
  • Appointed University Professor (2006)
  • American Psychological Association, Outstanding Contributions to Health Psychology Award (1999)


  • Publication 1091

    Forbes EE, Ryan ND, Phillips ML, Manuck SB, Worthman CM, Moyles DL, Tarr JA, Sciarrillo SR, Dahl RE. Healthy adolescents' neural response to reward:associations with puberty, positive affect, and depressive symptoms. J Am Acad Child Adolesc Psychiatry. 2010 Feb;49(2):162-72.e1-5.

  • Publication 249

    Manuck, S.B., Flory, J.D., McCaffery, J.M., Matthews, K.A.Mann, J.J., & Muldoon, M.F. (1998) Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology 19; 287-299

  • Publication 437

    Jennings, J.R., Muldoon, M.F., Hall, M., Buysse, D.J., & Manuck, S.B. (2007). Self-reported sleep quality is associated with the metabolic syndrome. Sleep, 30(2), 219-223.

  • Publication 506

    Gianaros PJ, Horenstein JA, Hariri AR, Sheu LK, Manuck SB, Matthews KA, & Cohen S. (2008). Potential neural embedding of parental social standing. Social Cognitive & Affective Neuroscience, 3, 91-96.

  • Publication 507

    Gianaros PJ, Matthews KA, Jennings JR, Sheu LK, Manuck SB, & Hariri AR (2008). Individual differences in stressor-evoked blood pressure reactivity vary activation, volume, and functional connectivity of the amygdala. Journal of Neuroscience, 28, 990-999.

  • Publication 508

    Gianaros PJ, Horenstein JA, Cohen S, Matthews KA, Brown SM, Flory JD, Critchley HD, Manuck SB, & Hariri AR (2007). Perigenual anterior cingulate morphology covaries with perceived social standing. Social Cognitive & Affective Neuroscience, 2, 161-173.

  • Publication 542

    Marsland, A.L., Gianaros, P.J., Abramowitch, S.M., Manuck, S.B., & Hariri, A.R. Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults. Biological Psychiatry 2008 64:484-490.

  • Publication 613

    Manuck, S.B., Phillips, J.E., Gianaros, P.J., Flory, J.D., & Muldoon, M.F. (in press). (2010). Subjective socioeconomic status and presence of the metabolic syndrome in midlife community volunteers. Psychosomatic Medicine.

  • Publication 614

    Halder, I., Marsland, A.L., Cheong, J., Muldoon, M.F., Ferrell, R.E., & Manuck, S.B. (in press). Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein. Brain, Behavior and Immunity 2009 Sept 29 [Epub ahead of print]

  • Publication 541

    Marsland, A.L., Prather, A.A.*, Petersen, K.L.*, Cohen, S., & Manuck, S.B. Antagonistic Characteristics are Positively Associated with Inflammatory Markers Independently of Trait Negative Emotionality. Brain, Behavior, and Immunity. 2008 22:753-61.

  • Publication 540

    Marsland, A.L., Petersen, K.L., Sathanoori, R., Flory, J.D., Muldoon, M.F., Neumann, S.A., & Manuck, S.B. Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers. Psychosomatic Medicine; 2006 68:895-903

  • Publication 539

    Marsland, A.L., Cohen, S., Rabin, B.S., & Manuck, S.B. Positive affect and antibody response to hepatitis B vaccination. Brain, Behavior and Immunity; 2006 20:261-269.

  • Publication 615

    Manuck, S.B., Marsland, A.L., Flory, J.D., Gorka, A., Ferrell, R.E., & Hariri, A.R. (in press). Salivary testosterone and a trinucleotide (CAG) length polymorphism in the androgen receptor gene predict amygdala reactivity in men. Psychoneuroendocrinology 2009 Jun 1 [Epub ahead of print]

  • Publication 618

    Manuck, S.B., Brown, S.M., Forbes, E.E., & Hariri, A.R. (2007). Temporal stability of individual differences in amygdala reactivity. American Journal of Psychiatry, 164, 1613-1614.

  • Publication 621

    Manuck, S.B., Bleil, M.E., Petersen, K.L., Flory, J.D., Mann, J.J., Ferrell, R.E., & Muldoon, M.F. (2005). The socio-economic status of communities predicts variation in brain serotonergic responsivity. Psychological Medicine, 35, 519-528.

  • Publication 620

    Manuck, S.B., Kaplan, J.R., & Lotrich, F.E. (2006). Brain serotonin and aggressive disposition in humans and nonhuman primates. In R.J. Nelson (Ed.), Biology of aggression (pp. 65-113). New York, Oxford University Press.

  • Publication 619

    Hariri, A.R., Brown, S.M., Williamson, D.E., Flory, J.D., de Wit, H., & Manuck, S.B. (2006). Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. Journal of Neuroscience, 26, 13213-13217.

  • Publication 617

    Kaplan, J.R., & Manuck, S.B. (2008). Ovarian dysfunction and the premenopausal origins of coronary heart disease. Menopause, 15, 768-776.

  • Publication 250

    Manuck, S.B., Flory, J.D., Ferrell, R.E., Dent, K.M., Mann, J.J., & Muldoon , M.F. (1999) Aggression and anger-related traits associated with a polymorphism of the tryptophan hydrocylase gene. Biological Psychiatry 45; 603-614.

  • Publication 120

    Kaplan, J.R., & Manuck, S.B. (1999) Status, stress, and atherosclerosis: The role of environment and individual behavior. Annals of the New York Academy of Sciences 896; 145-161.

  • Publication 631

    Hall M, Muldoon MF, Jennings JR, Buysse DJ, Flory JD, Manuck SB. Self-reported Sleep Duration is Associated with the Metabolic Syndrome in Mid-life Adults. Sleep, 31(5):635-643, 2008.

  • Publication 777

    Gianaros, P.J., Manuck, S.B., Sheu, L.K., Kuan, D.C., Votruba-Drzal, E., Craig, A.E., Hariri, A.R. (2011). Parental education predicts corticostriatal functionality in adulthood. Cerebral Cortex, 21, 896-910.

  • Publication 778

    Gianaros, P.J., & Manuck, S.B. (2010) Neurobiological pathways linking socioeconomic position and health. Psychosomatic Medicine, 72, 450-461.

  • Publication 616

    Gianaros, P.J., Hariri, A.R., Sheu, L.K., Muldoon, M.F., Sutton-Tyrrell, K., & Manuck, S.B. (2009). Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala. Biological Psychiatry, 65, 943-950.

  • Publication 868

    Kamarck, T.W., Muldoon, M.F., Manuck, S.B., Haskett, R.F., Cheong, J., Flory, J.D. & Vella, E. (2011) Citalopram improves metabolic risk factors among high hostile adults: Results of a placebo-controlled intervention. Psychoneuroendocrinology, 36, 1070-1079.

  • Publication 584

    Kamarck TW, Haskett RF, Muldoon M, Flory JD, Anderson B, Bies R, Pollock B & Manuck SB. Citalopram intervention for hostility: Results of a randomized clinical trial. Journal of Consulting and Clinical Psychology, 77, 174-188, 2009.

  • Publication 873

    Creswell, K.G., Sayette, M.A., Manuck, S.B., Ferrell, R.E., Hill, S.Y.& Dimoff, J.D. (2012). DRD4 Polymorphism Moderates the Effect of Alcohol Consumption on Social Bonding. PLoS ONE, 7(2) e29814, 1-9.

  • Publication 952

    Roecklein, K.A., Wong, P.M., Miller, M.A., Franzen, P.L., Ferrell, B.A., Manuck, S.B. (2012, in press). Melanopsin gene variations interact with season to predict sleep timing and chronotype. Chronobiology International.